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IOZK Immun-Onkologisches Zentrum Koln

Иммуно-Онкологический Центр Кельн IOZK
Cologne, Германия
0(1 reviews)
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About clinic

The IOZK in Cologne specialises in translating current research findings in immunology into effective treatments for people suffering from cancer. Our group developed and enabled the translation of the first autologous tumour vaccine in Europe, which is approved along the regulatory guidelines in the Medicines Act for advanced therapies. This vaccine is based on an autologous dendritic cell platform loaded with autologous tumour antigens that recognise immunological danger signals and is aided by a virus. Our tumour vaccine enables the patient's immune system to actively eliminate the tumour. Current standard therapies try to fight the tumour, but do not take into account the potential of the body's own defence mechanisms against tumour growth. Our therapy is based - adjacent to established therapies - on a combination of a specific immunotherapy that is tailored to the individual immunological and oncological needs of the patient. The term “personalised medicine" which is so often used today, is fully realised with our concept.
  • We utilize the potential of the patient's immune system to fight the growth of the tumour cells.
  • We use the patient's own tumour antigens (tumour cell material) as the tumour antigens are unique to a patient and their tumour.
  • We work with the patient's own immune cells (dendritic cells) that inform the immune system.
  • We make use of an oncolytic virus that replicates in tumour cells only, not in nomal healthy human cells. This leads to the tumour cells being marked for a targeted immune system attack.
  • We optimise the individual patient's supply of micronutrients and vitamins to enhance the body's immune system, Further oncolytic procedures, such as hyperthermia, are employed as indicated by the patient's condition.
  • Through combining our anti-tumour vaccination with checkpoint inhibitors, we open up new possibilities for treating advanced tumours.
  • We use an oncolytic virus which only replicates in tumour cells and does not affect healthy human cells. Through this the tumour cells are specifically marked for an attack by the immune system.
The complete cure of an advanced tumour can only be achieved in very rare cases through this type of therapy. But it can certainly influence the course of the disease positively and enhance the quality of life. Current results of our studies show an extended survival time when compared to the use of standard therapies alone.

Cost of diagnostics and operations

Diagnosis
Initial immunological oncological diagnostic3 500 €Enquire price
Follow-up immunological oncological diagnostics450 €Enquire price
Immunology
DC Vakzine18.800 €Enquire price
Isolation of the T-cells followed by Cryopreservation1 350 €Enquire price
Tumor-specific immunomodulation by means of five times oncolytic viro-therapy in combination Loco-Regional Radio Frequency4 500 €Enquire price

Patients' reviews

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Best clinic's doctors

Dr. Wilfried Stucker
Tumor Immunology
Work experience:
Achievements:

1985 Establishment of a network for ambulatory therapy of AIDS patients

1996 Foundation of a working group for complementary tumor therapy

2000 Foundation of a working group for immuno-oncological therapies

2002 Founding of today’s IOZK working group for the development of immuno-oncological therapies

2004 Opening of a cleanroom laboratory for active specific immunotherapy for the development and production of dendritic cells

2015 Obtaining the first GMP fabrication license for oncolytic viruses in Europe

2015 Obtaining the first GMP fabrication license for dendritic cells with autologous tumor antigens in combination oncolytic virus (NDV) in Europe

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Prof. Dr. Volker Schirrmacher
Tumor Immunology
Work experience:
Achievements:

Education

Diploma in Biochemistry PhD in Immunology

Stipend for Postdoc research in Stockholm, Sweden

Professional activities

Senior Research Fellow in London, UK

Head of Division Cellular Immunology at DKFZ, Heidelberg, Germany

Appointment to Ordinarius at the University Heidelberg Scientific Director of Tumorimmunology at IOZK, Cologne Awards

Aronson Award 1982 Meyenburg Award, 1982 German Cancer Award, 1988 Scientific Community

President of SEK, German Cancer Association President of the International „Metastasis Research Society” President of the „European Association of Applied Immunology e.V.”

Experience

Basic science in biochemistry, metastasis research, cellular immunology and tumor immunology

Adoptive immunotherapy studies with cancer-reactive memory T cells from bone marrow

Preclinical studies in animal tumor models and with human immune cells and tumor cells

Clinical studies of post-operative active-specific immunotherapy in various human carcinomas Multimodal immunotherapy at IOZK, Single case studies

 

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Stefaan Van Gool MD PhD
Specialist in Paediatric Hemato Oncology and immunology
Work experience:
Achievements:

Education

Degree of “geaggregeerde voor het hoger onderwijs”, 19/12/1994

Pediatric hemato-oncology, certificate in Belgium since 31/07/1996

Facharzt fur Kinder-und Jugendmedizin, certificate in Germany since 09/03/2016

Professional activities

Clinical staff Pediatric Oncology from June 1996 till March 2015

Professor at the KU Leuven between october 1996 and October 2016

Senior clinical investigator at the Fund for Scientific Research Belgium from October 2001 till September 2016 Medical director of translational oncology at the IOZK from September 2015

Awards

10 international and 8 Belgian scientific awards Scientific community

European high grade glioma working group coordinator July 2005 till June 2009

Co-Chair of SIOPE Brain Tumor Group July 2014 till June 2017 Member of the Health Supreme Court in Belgium 2008 till 2012

155 international peer-reviewed scientific publications Experience

Pediatric hemato-oncology with focus on neuro-oncology Basic science preclinical research in the domain of tumor immunology

Translational immuno-oncology for adults and children with solid tumors or brain tumors

Multimodal immunotherapy for adults and children with solid tumors or brain tumors

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Dr. med. Katharina Sprenger
Immune Oncology, general medicine
Work experience:
Achievements:
Specialist in General Medicine

Experience

Cooperation with IOZK since 2002

Cooperation with IOZK laboratory since 2012

Immune Oncology

Specialist in General Medicine

Qualfied Person (German Medicines Act)

Pharmacovigilance

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Dr. med. Tobias Sprenger
Specialist in General Medicine
Work experience:
Achievements:
Co-author of scientific publications Specialty: Specialist in General Medicine

Experience

comprehensive training in internal medicine, surgery, emergency and intensive medicine

Almost 20 years in ambulatory patient care, expert opinion activity

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