




Specialties: Oncology, Melanoma specialist.
Ronnie Shapira, MD. is an Oncologist at The Ella Institute for Immuno-Oncology in Sheba Medical Center which is implementing some of the world’s most advanced and unique treatment methodologies for melanoma and skin cancer. She is a Head of Onco-Gynecological cancer unit, leading the treatment of gynecological malignancies at the Oncology Institute.
Professional Expiriense:
Dr. Shapira-Frommer received her medical degree from Tel Aviv University, with a specialty in internal medicine. In 2004, she began working at Sheba, specializing in oncology. In 2010, she was appointed as a senior physician in the field of gynecology and oncology at the Ella Institute for Immuno-Oncology. Additionally, she became Head of the Gynecologic Oncology Unit at the Cancer Center in 2015.
Positions:
Professor Yakov Shekhter is Israel’s leading specialist in the treatment of skin tumors, the head of the country’s only center for the study of skin diseases, and the coordinator of research and development of immunotherapeutic drugs for the treatment of melanoma.
Deputy Head of the Oncology Department of the Medical Center named after Chaim Shiba, head of the Ella Institute for Research and Treatment of Skin Cancer.
Scientific activity:
Participation in professional organizations:
Professor Yossi Alkalay is a leading Israeli dermatologist, a world-class specialist in the treatment of dermatological and venereal diseases. Recognized medical expert, the first specialist to use the MOHS method in Israel to operate on oncodermatological diseases.
Education:
Professor Alkalay completed his studies with honors from the Sackler School of Medicine at Tel Aviv University. He specialized in venereology and dermatology at the hospital named after I. Rabin. For 3 years he improved his professional skills at the Oncology Center named after M. D. Anderson University of Texas. After which he studied the technique of performing operations using the MOHS method at the Baylor Medical College in Houston.
Scientific activity:
Membership in international associations:
Specialist in oncology, head of the oncology department at the Sourasky Medical Center, chairman of the National Council for Prevention, Diagnosis and Treatment of Malignant Diseases.
Education:
Academic activity:
Author of 60 presentations at scientific conferences and more than 40 professional publications in specialized international publications.
Membership in professional organizations:
Professor Eli Sprecher is a leading expert in the treatment of melanoma, as well as a wide range of different skin diseases.
Education:
Professional activity:
Scientific activity:
Specialization:
Education and clinical experience:
Author of more than 20 scientific articles.
Membership in specialized organizations:
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Treatment of melanoma in Israel, as well as non-melanoma skin cancer, is distinguished by the use of innovative techniques and drugs. For example, patients of Israeli clinics, including foreign ones, have access to:
In the most difficult cases, in the absence of effect from second-line therapy, skin cancer treatment in Israel allows patients to participate in clinical studies of experimental techniques. For example, in patients with progressive melanoma, Israeli oncodermatologists use:
According to Israeli clinics, the overall 5-year survival rate of patients with melanoma is 94%. This is the highest rate in the world, which is currently achievable only in the treatment of melanoma in the USA, Israel and Germany. At the same time, the cost of treating melanoma and other skin tumors in Israel is significantly less.
Skin cancer treatment in Israel is a guarantee that the patient will receive the most modern therapy available in global oncology.
The use of various combinations of immuno-oncological and targeted drugs of the latest generation in the treatment of skin cancer in Israel, which are not used in many other countries, provides a significant advantage for patients:
Immunotherapy and targeted therapy in Israel give patients with metastatic melanoma a chance of recovery. These treatments have been scientifically proven to be more effective for melanoma than chemotherapy. This causes fewer side effects. Therefore, it can be used in patients for a long time and maintain a good quality of life.
Melanoma, unlike non-melanoma – basal cell or squamous cell carcinoma, is an aggressive malignant tumor. Despite improvements in diagnostic and treatment methods, the incidence of melanoma is increasing.
However, treatment of melanoma in the early stages is not a problem: surgery ensures complete recovery. However, according to the World Health Organization (WHO), less than half of patients consult doctors with stage I of this cancer.
Successful therapy for melanoma, starting from stage II, includes immunotherapy and targeted therapy, which is carried out in full only in clinics abroad, primarily in the USA and Israel. At the same time, the price of melanoma treatment in Israel is significantly lower with the same high quality of medical services.
Israeli oncodermatologists, who are experts in the field of dermatology and oncology, examine all suspicious skin lesions using a dermatoscope. You can also attach a camera to the “skin microscope” with a built-in light source and a magnifying glass with 10-20x magnification. Therefore, dermatoscopy makes it possible to take pictures and study them on a computer monitor.
Using the latest generation digital dermatoscopes, Israeli specialists:
The qualifications and experience of Israeli oncodermatologists, advanced equipment and computer technology allow us to identify in 100% of cases:
After dermatoscopy, the doctor performs an excisional biopsy – excision of the tumor using special instruments. Using laboratory microscopic examination – the histology of the obtained tissues – the type of malignant cells and stage are determined – thickness, depth of tumor penetration into the skin, and a number of other indicators of cancer aggressiveness. Diagnosis of melanoma as the most malignant skin tumor has a number of features.
Melanoma quickly metastasizes: with a tumor thickness of up to 1 mm, they are detected in 2% of patients. For tumors more than 4 mm thick, metastases are found in 45% of patients. In 95% of cases, the first metastases appear in regional lymph nodes.
Therefore, in Israel, diagnosis of this type of cancer includes the following studies:
The sentinel lymph node is the first node to develop metastases when malignant cells spread beyond the primary tumor. It is visualized by injecting a radiopharmaceutical into the tumor area. A biopsy of such a lymph node makes it possible to determine the stage of the disease as accurately as possible.
Also in Israel, immunohistochemical examination of cells is performed to detect melanoma biomarkers, for example, the mitotic index. Innovative oncotests InVitae and FoundationOne CDx can detect the presence of mutations in the BRAF, MEK, C-KIT genes in order to prescribe targeted therapy.
The main treatment method for non-melanoma skin cancer in Israel, which is usually detected in the early stages, is surgery. The doctor chooses a tumor removal technique depending on:
Skin cancer treatment in Israel may include the following types of surgery:
If patients have contraindications to surgery, non-melanoma skin cancer can be treated with modern radiotherapy, which is as effective as surgery.
In the treatment of skin cancer in Israel, photodynamic therapy, local chemotherapy (chemo- and immunotherapeutic ointments and gels), and electrochemotherapy are also used.
Several targeted drugs of the latest generation are successfully used in Israel for the treatment of locally advanced and metastatic basal cell carcinoma and its relapses. For the treatment of advanced squamous cell carcinoma, a treatment protocol is used that includes targeted and immunotherapy. An effective immunotherapy drug currently used in Israel provides partial or complete cure in 50% of patients with advanced squamous cell carcinoma.
Mohs surgery (Mohs) is considered the gold standard treatment for non-melanoma skin cancer and some superficial melanomas in Israel. It is recommended for tumors located near the eyes, nose, lips, ears, scalp, fingers, toes, and genitals. Treatment of skin cancer in Israel using Mohs surgery is also carried out for large, ill-defined, rapidly growing recurrent tumors.
Mohs micrographic surgery is:
The exact cost of treating melanoma and other types of cancer in Israel using Mohs surgery can be obtained from the coordinating doctors of Experts Medical.
Israeli oncodermatologists completely cure stage I melanoma using a surgical procedure. The main methods of treating stage II-III melanoma in Israel are surgery, immunotherapy and targeted therapy.
Melanoma surgery is a wide excision of the primary tumor without or with removal of regional lymph nodes when malignant cells are detected in the sentinel lymph node. Patients with BRAF mutations, who account for 50% of cases, are treated with targeted therapy and immunotherapy. Patients without a BRAF mutation receive immunotherapy only.
Treatment regimens may include different classes of targeted and immuno-oncology drugs: interferons, interleukins, monoclonal antibodies, BRAF/MEK and immune checkpoint inhibitors.
Although many patients with stage IV melanoma have the primary tumor removed, the mainstay of treatment is immunotherapy, including cell-based (TIL) and targeted therapy.
Chemotherapy is used in selected patients: most often, it complements the main course of treatment or is prescribed as second-line therapy. Conventional radiation therapy is not used to treat the primary tumor. Metastases in the brain, bones and other areas of the body are treated with stereotactic radiotherapy and radiosurgery (Gamma Knife, CyberKnife).
In advanced cases, oncologists perform chemoembolization of liver metastases, chemotherapy isolated perfusion of the limb affected by the tumor, and other high-tech methods of treating metastatic cancer.
At the same time, the price of melanoma treatment in Israel is significantly lower than in the USA and Germany with similar treatment success rates.
TIL (tumor-infiltrating lymphocytes) technology allows you to use your own “tumor-infiltrating lymphocytes” to destroy cancer cells. In melanoma patients, in the removed tumor they often find single cells of their own immune system, which appeared in it to fight cancer. In laboratory conditions, a cell clone is grown from them, prepared for the destruction of melanoma cells. A huge amount of TIL is injected into the patient’s blood along with an immunodrug from the interleukins group.
Treatment of melanoma in Israel using TIL cell immunotherapy is carried out in several clinics.
Treatment of melanoma in Israel, as well as non-melanoma skin cancer, is successfully treated by qualified oncodermatologists in the Sourasky, Assuta, Rambam, and Beilison clinics. Israel also has outstanding world-class specialists:
Professor Yakov Schechter, who directs the Institute of Immuno-Oncology and Melanoma Research at the Sheba Clinic and collaborates with the American National Cancer Institute (NCI) and the MD Anderson Cancer Center;
Professor Michal Lotem, head of the Melanoma Research and Treatment Center at Hadassah Medical Center, which specializes in the treatment of this disease with oncolytic vaccines.
Experts Medical will help organize consultations with professors, as well as treatment of melanoma in Israel, by receiving an application on the website.
The final cost depends on many factors, including the number of necessary diagnostic and treatment procedures, the immunotherapy protocol and targeted therapy, which is prescribed only after a full examination and clarification of the stage of the disease. It also depends on the status of the clinic (private and public).
For example, the cost of dermatoscopy in Israeli clinics varies from $100 to $220. The estimated average cost of melanoma treatment in Israel is $29,000-34,000.
Therefore, it is best to discuss the cost of melanoma treatment in Israel with the Experts Medical coordinating doctor, who will recommend a clinic and doctor taking into account the patient’s financial capabilities.
Leave a request on the Experts Medical website. Service specialists will quickly select a clinic and oncodermatologist for you with good reviews from patients, provide a treatment plan, help you create a travel budget and organize comfortable conditions for your stay in the country. And also during treatment for skin cancer in Israel they will provide assistance with any questions.