➤ Bone Marrow Transplant in Turkey: Top 3 Clinics❤️ Cost of bone marrow transplantation abroad and patient reviews
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Bone marrow transplant in Turkey

  • Below you will find the ranking of the best oncohematologists in Turkey and bone marrow transplantation clinics
  • The clinics are selected based on the effectiveness of treatment, the qualifications of doctors, the ratio of price and quality, the level of service, and the equipment producibility.
  • We personally checked these clinics and can recommend them to our patients.
  • We help paying treatment for children under 18 years of age.
Help pay for treatment
Experts Medical cooperates with foreign funds that help our patients pay for treatment
You can receive compensation up to 20,000 euros for the treatment of a patient under the age of 18

The best oncohematologists in Turkey

Prof. Ahmet Demir
Oncohematologist
Work experience: over 18 years
Achievements:

Dr. Demir works at Memorial Ankara Clinic. He specializes in the treatment of neuroblastomas and other childhood oncologies. He performs a bone marrow transplant. Medical experience is more than 20 years.

Member of international societies:

  • International Society of Pediatric Oncology (SIOP);
  • Turkish Association of Pediatric Oncology (TPOG);
  • Eastern and Mediterranean Group of Pediatric Oncology (POEM);
  • Turkish Medical Association (TTB).
Contact doctor
Prof. Akif Yeshilipek
Pediatric onco-hematologist, specialist in bone marrow transplantation
Work experience: over 31 year
Achievements:

2010-2015: Member of the Scientific Committee on Hemoglobinopathies of the Ministry of Health.

2008-2012: Member of the Stem Cell Science Council of the Ministry of Health.

2009-2013: Commission for Pediatric Hematology and Oncology. Member of the Council of Medical Specialties.
2013-2018: TÜBA Stem Cell Scientific Committee

He is a member:

  • European Group for Blood and Bone Marrow Transplantation (EBMT)
  • American Society of Hematology (ASH)
  • European Hematology Association (EHA)

Author of 113 scientific publications.

 

Contact doctor
Prof. Birol Baytan
Oncohematologist
Work experience: over 25 years
Achievements:

Prof. Baitan is an experienced bone marrow transplantologist.

He specializes in the diagnosis and treatment of oncological diseases in children, bleeding, anemia, vascular diseases and much more.

Professor Baytan has published over 30 articles in international and Turkish peer-reviewed journals.

He is also the author and co-author of 3 books.

Contact doctor
Professor Gulyuz Ozturk
Oncohematologist
Work experience: over 29 years
Achievements:

Professor Gülyüz Öztürk graduated from the Medical Faculty of Ankara University. Awarded the title of professor at Hacettepe University.

Contact doctor

Best clinics for bone marrow transplant in Turkey

Check the cost of treatment and get 20 000 € from international foundation

Get financial help up to 20 000 € for your child treatment

Calculate the cost of treatment abroad
1 How old is the patient?
0-18
19-35
36-60
older than 60
Your discount: €0
Nataliia Storozhenko

Medical consultant

Please, answer a few questions to evaluate the possibility of paying for treatment for you and get individual advice on financing options.
Calculate the cost of treatment abroad
2 What is the patient's diagnosis?
Oncology
Cardiology
Neurosurgery
Orthopedics
Urology
Gynecology
Rare diseases
Your discount: €40
Calculate the cost of treatment abroad
3 What kind of treatment is recommended?
Brain or vertebral surgery
General (abdominal) surgery
Orthopedic surgery
Plastic surgery
Radiotherapy
Chemotherapy
Online consultation with a foreign doctor
Your discount: €80
Calculate the cost of treatment abroad
4 In which country are you planning to undergo treatment?
Turkey
Israel
Germany
Spain
Italy
Lithuania
Poland
Your discount: €120
Calculate the cost of treatment abroad
5 When do you plan to go for treatment?
Less than 10 days
10 - 30 days
1 - 2 months
More than 2 months
Your discount: €160
Calculate the cost of treatment abroad
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from €1800
€2000
Your discount: €200

Turkish oncologist will provide an individual chemotherapy program.

Doctor-consultant will select the best specialist, draw up an individual price offer for you and help you at all stages of organizing and undergoing treatment.
from €5800
€6000
Your discount: €200

Israeli oncologist will provide an individual chemotherapy program.

Doctor-consultant will select the best specialist, draw up an individual price offer for you and help you at all stages of organizing and undergoing treatment.
from €4800
€5000
Your discount: €200

Spanish oncologist will provide an individual chemotherapy program.

Doctor-consultant will select the best specialist, draw up an individual price offer for you and help you at all stages of organizing and undergoing treatment.
from €7800
€8000
Your discount: €200

German oncologist will prepare an individual chemotherapy program.

Doctor-consultant will select the best specialist, draw up an individual price offer for you and help you at all stages of organizing and undergoing treatment.
from €1800
€2000
Your discount: €200

Polish oncologist will prepare an individual chemotherapy program.

Doctor-consultant will select the best specialist, draw up an individual price offer for you and help you at all stages of organizing and undergoing treatment.
from €3800
€4000
Your discount: €200

Italian oncologist will prepare an individual chemotherapy program.

Doctor-consultant will select the best specialist, draw up an individual price offer for you and help you at all stages of organizing and undergoing treatment.
from €4800
€5000
Your discount: €200

Turkish radiologist will prepare a personalized radiation therapy program

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing radiation therapy.
from €6800
€7000
Your discount: €200

Israeli radiologist will draw up an individual radiation therapy program.

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing radiation therapy.
from €6800
€7000
Your discount: €200

German radiologist will draw up an individual radiation therapy program.

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing radiation therapy.
from €4800
€5000
Your discount: €200

Spanish radiologist will draw up an individual radiation therapy program.

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing radiation therapy.
from €4800
€5000
Your discount: €200

Polish radiologist will prepare an individual radiation therapy program.

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing radiation therapy.
from €4800
€5000
Your discount: €200

Italian radiologist will draw up an individual radiation therapy program.

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing radiation therapy.
from €1800
€2000
Your discount: €200

Turkish plastic surgeon will make an individual operation program.

Doctor-consultant will select the best doctor for your renewed beauty.
from €4800
€5000
Your discount: €200

German plastic surgeon will make an individual operation program.

Doctor-consultant will select the best doctor for your renewed beauty.
from €4800
€5000
Your discount: €200

Israeli plastic surgeon will make an individual operation program.

Doctor-consultant will select the best doctor for your renewed beauty.
from €2800
€3000
Your discount: €200

Italian plastic surgeon will make an individual operation program.

Doctor-consultant will select the best doctor for your renewed beauty.
from €1300
€1500
Your discount: €200

Polish plastic surgeon will make an individual operation program.

Doctor-consultant will select the best doctor for your renewed beauty.
from €2800
€3000
Your discount: €200

Spanish plastic surgeon will make an individual operation program.

Doctor-consultant will select the best doctor for your renewed beauty.
from €6800
€7000
Your discount: €200

Turkish orthopedic surgeon will make an individual operation program.

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing surgical treatment.
from €9800
€10000
Your discount: €200

Israeli orthopedic surgeon will make an individual operation program.

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing surgical treatment.
from €9800
€10000
Your discount: €200

German orthopedic surgeon will make an individual operation program.

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing surgical treatment.
from €6800
€7000
Your discount: €200

Italian orthopedic surgeon will make an individual operation program.

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing surgical treatment.
from €4800
€5000
Your discount: €200

Lithuanian orthopedic surgeon will make an individual operation program.

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing surgical treatment.
from €4800
€5000
Your discount: €200

Polish orthopedic surgeon will make an individual operation program.

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing surgical treatment.
from €800
€1000
Your discount: €200

Ukrainian orthopedic surgeon will make an individual operation program.

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing surgical treatment.
from €5800
€6000
Your discount: €200

Spanish orthopedic surgeon will make an individual operation program.

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing surgical treatment.
from €14800
€15000
Your discount: €200

Turkish neurosurgeon will study the medical situation and give recommendations for treatment.

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing surgical treatment.
from €19800
€20000
Your discount: €200

Israeli neurosurgeon will study the medical situation and give recommendations for treatment.

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing surgical treatment.
from €19800
€20000
Your discount: €200

German neurosurgeon will study the medical situation and give recommendations for treatment.

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing surgical treatment.
from €14800
€15000
Your discount: €200

Italian neurosurgeon will study the medical situation and give recommendations for treatment.

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing surgical treatment.
from €9800
€10000
Your discount: €200

Lithuanian neurosurgeon will study the medical situation and give recommendations for treatment.

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing surgical treatment.
from €9800
€10000
Your discount: €200

Spanish neurosurgeon will study the medical situation and give recommendations for treatment.

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing surgical treatment.
from €1300
€1500
Your discount: €200

Ukrainian neurosurgeon will study the medical situation and give recommendations for treatment.

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing surgical treatment.
from €200
€400
Your discount: €200

Turksih doctor will answer your questions

If you have doubts about your treatment recommendation or are unsure about your diagnosis, one of the best foreign doctors may answer your questions.
from €700
€900
Your discount: €200

Israeli doctor will answer your questions

If you have doubts about your treatment recommendation or are unsure about your diagnosis, one of the best foreign doctors may answer your questions.
from €400
€600
Your discount: €200

German doctor will answer your questions

If you have doubts about your treatment recommendation or are unsure about your diagnosis, one of the best foreign doctors may answer your questions.
from €400
€600
Your discount: €200

Italian doctor will answer your questions

If you have doubts about your treatment recommendation or are unsure about your diagnosis, one of the best foreign doctors may answer your questions.
from €300
€500
Your discount: €200

Polish doctor will answer your questions

If you have doubts about your treatment recommendation or are unsure about your diagnosis, one of the best foreign doctors may answer your questions.
from €200
€400
Your discount: €200

Ukrainian doctor will answer your questions

If you have doubts about your treatment recommendation or are unsure about your diagnosis, one of the best foreign doctors may answer your questions.
from €400
€600
Your discount: €200

Spanish doctor will answer your questions

If you have doubts about your treatment recommendation or are unsure about your diagnosis, one of the best foreign doctors may answer your questions.
from €9800
€10000
Your discount: €200

Israeli orthopedic surgeon prepare an individual surgical plan and recomendations

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing surgical treatment.
from €7800
€8000
Your discount: €200

Turkish orthopedic surgeon prepare an individual surgical plan and recomendations

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing surgical treatment.
from €9800
€10000
Your discount: €200

German orthopedic surgeon prepare an individual surgical plan and recomendations

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing surgical treatment.
from €6800
€7000
Your discount: €200

Italian orthopedic surgeon prepare an individual surgical plan and recomendations

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing surgical treatment.
from €4800
€5000
Your discount: €200

Lithuanian orthopedic surgeon prepare an individual surgical plan and recomendations

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing surgical treatment.
from €4800
€5000
Your discount: €200

Polish orthopedic surgeon prepare an individual surgical plan and recomendations

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing surgical treatment.
from €5800
€6000
Your discount: €200

Spanish orthopedic surgeon prepare an individual surgical plan and recomendations

Doctor-consultant will select the best specialist and help at all stages of organizing and undergoing surgical treatment.
from €200
€400
Your discount: €200

Lithuanian doctor will answer your questions

If you have doubts about your treatment recommendation or are unsure about your diagnosis, one of the best foreign doctors may answer your questions.

After examining your situation, doctor will make an individual price offer.

Doctor-consultant will answer all your questions about the cost of treatment, the choice of a doctor and fully organize treatment abroad.

Patient reviews about Bone marrow transplantation in Turkey
Send review
5/5
Rating:
Diagnosis: leukemia

I was treated in Acibadem. Until now, the warmest memories are of the nurse girls, translators, managers, attending physicians who have been with me all this time. Medicine is head and shoulders above that in Russia. Everything is better organized and the attitude is much more humane. I was met at the airport, taken and placed in the ward. I passed all the examinations without haste and fuss, in just a couple of days. The doctor spoke to me on the day of admission. Helped with the preparation of the necessary documents. I had a good bone marrow transplant operation. During the preparation, I was very afraid and worried, but there was a psychologist who worked with me a lot. Now i am home. I’m in remission. I hope that there will be no more relapses and I advise everyone not to wait and not to doubt, but to immediately seek help from good clinics. This is where they really help you.


27/01/2019
5/5
Rating:
Diagnosis: bone marrow transplantation

I want to thank Maria Rybalova for helping me find a good specialist! In a difficult situation, your help is invaluable! Thank you for your professionalism, attention, efficiency and kindness.


20/09/2022
5/5
Rating:
Diagnosis: acute leukemia

For 4 years, the phenomenal doctors of the hemato-oncology department of the Medipol hospital fought for the life of our child. Each of his smiles is their achievement. We are infinitely grateful to all the doctors who accompanied us on this difficult path and to the nurses who cared for the child with motherly patience. This is the hardest test for any parent. But the relentless perseverance and confidence of the doctors did not let us fall into despair. Our baby managed to overcome the disease.


15/05/2020
5/5
Rating:
Diagnosis: leukemia

My 19 year old son had a bone marrow transplant. We express our deep gratitude to Professor Deniz, her team of resuscitation doctors, and junior medical staff for their professionalism and kindness. Special thanks to the coordinator of the international department Svetlana, translators Aida, Zhyldyz, Davud and others, the guys coordinating the transfer of Sino, Nurali and others, as well as the drivers. Thank you all for your kindness and generosity. We do not regret choosing the Medipol clinic


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Bone Marrow Transplant Programs

Alogenous bone marrow transplantation from an undisputed donor

  • Hospitalization: 60 days
  • Trip duration: 120 days
  • PAYMENT HELP FROM EXPERTS MEDICAL: up to 11,000 USD (PATIENTS UNDER 18)
  • Day 1: Meeting at the airport, hospitalization
  • Days 2-7: examination
  • Day 8: Bone marrow transplantation
  • Day 60: Check-out, hotel check-in
  • Day 61: Outpatient observation
  • Day 120: Airport transfer

Autologous bone marrow transplantation

  • Hospitalization: 45 days
  • Trip duration: 70 days
  • PAYMENT HELP FROM EXPERTS MEDICAL:: up to 11,000 USD (PATIENTS UNDER 18)up to 11,000 USD (PATIENTS UNDER 18)
  • day 1: Meeting at the airport, hospitalization
  • days 1-4: Examination, collection of stem cells
  • day 5: Immunotherapy
  • days 7-11: High dose chemotherapy
  • day 12: Autologous bone marrow transplant
  • day 45: Check-out, hotel check-in
  • day 45-69: Outpatient control and medical supervision
  • day 70: Airport transfer
What is a bone marrow transplant?

Bone marrow transplantation (BMT) is a procedure to inject and engraft healthy bone marrow (own or donor) to replace an abnormal hematopoietic organ. A more accurate modern term for this procedure is “hematopoietic stem cell transplant,” which is a transplant of hematopoietic stem cells that reside in the bone marrow. 

The first successful bone marrow transplant was performed in New York City in 1957 on a patient with acute leukemia. Dr. Thomas, who performed the procedure, received a Nobel Prize for developing this treatment.

BMT is the primary technique for treating blood cancers.

What is bone marrow transplant cost in Turkey?

The price of autologous transplantation is on average $ 36,000, and the cost of allogeneic bone marrow transplantation in Turkey is from $ 80,000. Prices for this type of treatment in Germany and Israel are much higher – up to 50%.

The bone marrow transplant cost in Turkey may slightly differ in one direction or another depending on the price level in each individual clinic. The price difference may vary for individual components of the procedure. For example, the price of donor material, and donor travel for stem cell donation.  

Why BMT is often performed in Turkey?

Bone marrow transplant in TurkeyBone marrow transplant in Turkey significantly increases the effectiveness of treatment for patients. It gives a chance for complete recovery or long remissions in severe hematologic and oncologic diseases. That is why this procedure is put on stream in Turkish clinics.

 

Where do they get bone marrow for transplantation in Turkey? 

Healthy hematopoietic stem cells are obtained in Turkish medical centers in three ways: 

  • from the patient’s own bone marrow or from a healthy donor;
  • from the patient’s own or donor’s peripheral blood;
  • from umbilical cord blood (donor blood, stored frozen in the Cord Blood and Marrow Banks, or the patient’s blood obtained at birth).

BMT in Turkey is a frequently used surgery in clinical practice. In several severe diseases, it is performed by a whole team of highly specialized doctors in a specialized medical center. They are connected with international registries of bone marrow donors.

What is new in bone marrow transplant in Turkey?

New transplantation technologies are constantly appearing in Turkey. For example, T-cell depletion, and new drugs that improve the results of transplants.  

The T-cell depletion method is the removal of immune T-cells from the donor bone marrow before transplantation in Turkey. This significantly reduces the risk of graft versus host reaction, which is important when engrafting bone marrow from partially compatible donors.

What types of bone marrow transplants are performed in Turkey?

TYPES OF BONE MARROW TRANSPLANTAs in European and Israeli clinics, Turkish specialized centers perform all existing types of bone marrow transplants:

  • Autologous BMT is a procedure of transplanting the patient’s own normal stem cells. They are extracted from the patient’s bone marrow and injected into the patient during certain periods of the disease. They may be received during remission, or administered during high-dose chemotherapy to maintain and restore hematopoiesis and immunity.
  • Allogeneic transplantation in Turkey is an operation to transplant healthy bone marrow from related or unrelated donors to the recipient.

Depending on who becomes the donor, allogeneic bone marrow cell transplants are of three types: 

  • from a fully compatible related donor, with a separate transplant from an identical twin (syngeneic transplant);
  • from a partially compatible related donor (haploidentical transplant); 
  • from a fully compatible unrelated donor. 

The most complicated procedure is considered to be allogeneic haploidentical transplantation, which is performed only in large clinics with innovative equipment. Such conditions are necessary to prepare the donor material, which significantly improves the patient’s prognosis of engraftment of the transplanted bone marrow.  

What diseases are Bone Marrow Transplant performed in Turkey?

The procedure of injecting normally functioning stem cells, from which all the formative elements of blood (red blood cells, white blood cells and platelets) are formed, is performed in many diseases. This can be oncology and other diseases of the blood system. 

bmt TurkeyIndications for allogeneic bone marrow transplant in Turkey

  • acute lymphoblastic leukemia; 
  • acute myeloid leukemia; 
  • myelodysplastic syndrome; 
  • chronic myeloid leukemia; 
  • multiple myeloma; 
  • aplastic anemia;
  • thalassemia;
  • sickle cell anemia; 
  • Fanconi anemia;
  • severe combined immunodeficiency syndrome. 

Autologous bone marrow transplant in Turkey is usually reserved for patients with Hodgkin’s and non-Hodgkin’s lymphoma after high-dose chemotherapy. The aim is to maintain and restore the bone marrow after the use of aggressive drugs. Such measures increase the effectiveness of comprehensive therapy aimed at complete recovery or correction of relapse. 

Stem cells from bone marrow are also transplanted to patients receiving high-dose chemotherapy or radiation therapy. Such treatment is used in certain types of oncology (breast cancer, neuroblastoma). This method is suitable for the treatment of autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, and some other pathologies. 

Why is bone marrow transplant in Turkey suitable for many patients?

Bone marrow transplant with the best ratesBone marrow transplants with the best results in the world are performed in clinics in the USA, some European Union countries (primarily Germany), Israel, and Turkey. From a financial point of view, it is much cheaper to perform BMT in Turkish clinics than in American or European ones.

In the former CIS countries, BMT is available to only a few patients who need it. Often, transplantation is only possible in some clinics in large cities. Even transplantation of one’s own bone marrow is not always performed at the level of modern international standards. This is due to the lack of modern equipment, technologies and experienced doctors in hospitals. Also, a special mode of nursing for patients during the first 3 weeks after bone marrow transplant is not provided at the proper level. The medical staff cannot conduct high-level rehabilitation within 100 days after the procedure, which is extremely important for the result, the effectiveness of the whole treatment, and a favorable prognosis of the disease. 

Donor cell transplantation is also difficult in the presence of a partially compatible related donor (due to the lack of necessary technologies for cell preparation in such cases). The lack of a suitable relative for bone marrow donation, or an insufficient national registry of potential unrelated donors, becomes a problem. A key disadvantage is the lack of integration of hematology departments with international bone marrow donor registries. 

In such a case, searching for a donor in international medical databases and its activation (obtaining bone marrow and its transportation, or appointment the donor to the clinic) becomes an expensive medical service. Therefore, in case of malignant blood diseases, it is advisable to immediately consider the option of BMT in a specialized medical center abroad. 

Why go for a bone marrow transplant in Turkey?

Due to the rapid state-of-the-art of oncohematology and transplantation medicine, in many BMT departments in Turkish clinics, this procedure is performed at a high international level. The result of successful engraftment of the donor material as in European clinics (from 90%). At the same time, the cost of bone marrow transplant in Turkey is significantly lower than in German or Spanish clinics. Medical service is patient-centric for patients from abroad.

bone marrow transplant cost in turkeyIn the Bone Marrow Transplant Centers of the Medical Park Clinic Network in 2021:

  • the survival rate in the first 100 days after bone marrow transplant in children from donors in 2 centers out of 4 Medical Park Antalya and Medical Park Bahcelievler was 100%;
  • The survival rate in the first 100 days after BMT in adult patients from donors at Medical Park Antalya and Medical Park Geztepe clinics was 95%. 

In 2021, Seckin Erdal, President of the Turkish Nurse Group at EBMT, received the Outstanding Service Award for nurses working in Bone Marrow Transplant Centers in Turkey at the Annual Congress of the European Society of Bone Marrow Transplantation (EBMT). She works at the Acibadem Clinic

This shows the high international level of qualification of all specialists – both doctors and nurses working in Turkish clinics. 

 

How many bone marrow transplants are performed in Turkey?

In the five specialized centers of Medical Park Clinic in 2021 in adult patients were performed:

  • 248 autotransplants and 133 BMTs from a fully compatible related donor;
  • 36 haploidentical bone marrow transplants and 95 bone marrow transplants from unrelated donors. 
  • Children had the most allogeneic transplants from related donors – 253, from unrelated donors -153. 

Also haploidentical bone marrow transplant in Turkey is put on stream in specialized centers of Acibadem Clinic

How is autologous bone marrow transplantation performed in Turkey clinics?

bone marrow transplant centersAutologous bone marrow transplantation involves several stages:

  1. Doctors safely collect stem cells from the patient’s bone marrow by aspiration under general anesthesia. The material is taken from the iliac bone (if necessary – from the sternum) or peripheral blood after stimulation with special drugs to release stem cells from the bone marrow into the blood. 
  2. Morphologists examine the resulting cellular material to exclude the content of abnormal cells. It is then purified of unnecessary elements and the isolated stem cell fraction is frozen for storage until transplantation.
  3. The patient’s stem cells are injected into specific body areas. The site of injection depends on the type of transplant and the nature of the disease. Typically, donor bone marrow is injected into the medullary cavity of large bones, such as the pelvic or chest bones. This location ensures efficient distribution of stem cells and their entry into the bloodstream, from where they can migrate to the bone marrow and begin the regeneration process.

The procedure of injecting donor bone marrow is usually done surgically. The bone marrow can be injected into the recipient’s body through a vein (venous infusion) or using a special tube inserted directly into the bone marrow (bone marrow infusion).

How is allogeneic bone marrow transplantation performed in Turkey?

Donor bone marrow transplantation with a good outcome is a complex process. It involves many medical components and stages with the participation of a whole team of specialists: 

Donor selectionDonor selection.

This is one of the most important stages, which largely determines the outcome of the transplant. It can be an evaluation by doctors of a relative as a donor. It is also possible to select and activate a donor from the national Turkish or international registry. In Turkey, it is possible to obtain donor material from the International Cord Blood and Bone Marrow Bank.

Patient and donor compatibility testing. 

Within 4-5 days, the patient and donor undergo a thorough preoperative examination to determine the degree of compatibility (full or partial), primarily compatibility by HLA tissue antigen. 

Stem cell collection from the donor.

Cells are obtained from the donor’s peripheral blood using venous catheters in two arms. Blood is drawn through one and passed through a special machine to collect stem cells. Through the other, the blood is returned to the donor. It usually takes several such sessions over 2 days. The time the donor needs to stay in Turkey to receive the material for transplantation and recovery usually does not exceed 10 days. The cells obtained are processed and stored frozen until administration to the patient.

Preparation of the patient for donor cell transplantation (conditioning regimen).

The goal of the conditioning regimen is to destroy any remaining malignant cells in the recipient’s bone marrow and suppress the immune system for successful engraftment of the donor stem cells. This is accomplished by doctors administering chemotherapy according to a specific international protocol. The duration of chemotherapy for fully HLA-compatible allogeneic transplants is 6 days. For compatible cells from unrelated donors, it is 7 days and for haploidentical cells, it is 9 days. 

Patient administration of donor stem cells. 

One day after chemotherapy, donor stem cells are administered to the patient by slow infusion over 2 hours under the doctor’s supervision. 

Prevention and treatment of complications in the patient during the period of bone marrow suppression. 

At the end of conditioning and before the transplanted stem cells begin to function, the patient develops a state of complete suppression of their own bone marrow. It is manifested by almost complete absence or extremely low content of red blood cells, leukocytes and platelets in the patient’s peripheral blood. The process lasts on average 3 weeks after BMT.   

In the postoperative period, life-threatening complications can develop severe infections, up to sepsis and severe bleeding. Therefore, during this period, the patient is kept in a special sterile box with HEPA filters and lives in sterile conditions.

Doctors conduct careful round-the-clock monitoring of the patient’s condition and blood counts. The recipient receives all necessary therapy to prevent and treat complications, and support good health: infusion of blood components, antibacterial therapy, symptomatic agents. Additionally, the patient is provided intravenous nutrition and care.

To prevent rejection of transplanted cells, doctors prescribe immunosuppressants. These are special drugs to suppress the body’s immune response to foreign cells.  

Engraftment of healthy donor stem cells and restoration of hematopoiesis. 

Stem cells begin to engraft about 10 days after administration. During this period, blood counts gradually increase. Then, the patient can be discharged from the sterile box for further observation in a regular ward, where he can already live with a relative. One month after the transplant, doctors perform a bone marrow analysis, which shows that the donor cells are “in place” and functioning normally. 

Then the patient can leave the medical facility and live in a hotel at the clinic, continuing to be monitored by doctors. After another month, the patient can return home if the blood test results are satisfactory and the general condition is stable. 

Usually, from the day of hospitalization in a Turkish clinic to the day of return to your country, it takes 2-3 months. This period may increase if there are severe infectious complications or blood counts are slowly recovering. 

After returning home, the patient stays in touch with his/her attending physician and can return to the clinic for treatment if there are any complications. Full rehabilitation of the patient after a bone marrow transplant in Turkey takes from 3 to 12 months. After 100 days from the moment of the procedure, if there are no complications, it is considered that the transplant was successful. 

What are the advantages of this procedure when performed in Turkish clinics?

Turkish bone marrow transplant clinicsPerforming BMT in Turkish medical centers has a number of important advantages: 

  • Optimal price-quality ratio. The cost of bone marrow transplant in Turkey is significantly lower (up to 50%) than in European hospitals. This also applies to the cost of the entire stay in Turkey during BMT, as the prices in this country for almost everything necessary during the entire trip are lower than in Europe, the USA and Israel.
  • All BMT centers in clinics in Turkey are members of the European Society for Bone Marrow Transplantation (EBMT). They work according to the latest European and international protocols for transplantation.
  • In Turkey, the most complex haploidentical bone marrow transplants have been organized in several clinics due to the latest technologies in the preparation of the material for transplantation. In particular, T-cell depletion. 
  • There are many hematologists of world renown working in Turkish cities. Doctors of clinics where the procedure is performed regularly undergo training with leading specialists from the USA and Europe. They attend thematic congresses, including annual EBMT medical events. Oncohematologists in Turkey have authority in the international medical community.
  • The level of equipment of all medical structures and services related to bone marrow transplantation (laboratories, sterile boxes, cell storage banks) in the clinics of Turkey corresponds to the best world standards.
  • Bone marrow transplant centers in Turkish clinics have sufficient capacity to select healthy donors and transplant material through an approach to international registries. 
  • Turkish clinics have excellent patient care conditions. A favorable psychological climate is especially important when undergoing such a complex and long treatment. Adult patients and children feel comfortable in modern hospitals. 
  • Oncohematology departments in Turkey have accumulated extensive experience in treating foreign patients with hematologic and oncologic diseases.
  • The medical staff of clinics in Turkey accepts foreign patients at a decent level, as evidenced by numerous positive reviews. There is no language barrier in Turkish hospitals. All treatment is organized taking into account the religious and cultural preferences of visitors.

All the above factors significantly improve the prognosis in bone marrow transplantation. Therefore, Turkey is one of the key destinations where it is advisable for patients to go for diagnosis, treatment and rehabilitation of hematologic diseases and oncopathologies.

Which clinics in Turkey are considered the best for bone marrow transplantation?

Turkey has many medical centers with the necessary international accreditations. Patients come there from England, the USA and Kazakhstan. 

According to research conducted by the Turkish Ministry of Healthcare, in 2018, Medical Park Clinic in Antalya ranked 1st among the top five medical centers in the country with the highest rates of performed bone marrow transplants for children. 

The specialized centers of Ajibadem clinics perform the high-tech procedure of T-cell depletion. This is the removal of cells from the donor material before transplantation, which can cause a strong immune response and bone marrow rejection. The procedure significantly increases the effectiveness of BMT and increases the chances of a favorable outcome – engraftment of stem cells from incompatible donors. 

How to organize bone marrow transplant in Turkey clinics?

How to organize bone marrow transplant in Turkey clinicsExpertise is required to organize such a complex, lengthy and expensive treatment abroad. Sufficient experience of a particular medical institution and the availability of all necessary professionals in it play a role in the choice of a clinic.

In the financial matter, the cooperation of a medical tourism organization with charitable foundations is an advantage. In some cases it allows to compensate a part of the cost of medical services for the child.

Experts Medical coordinating doctors know all the possibilities of bone marrow transplant centers in several clinics in Turkey. They keep in touch with leading doctors in the field of hematology and oncology. When choosing a medical center, they always take into account the feedback from patients who have undergone BMT

Leave a request on the website for a free consultation. Experts Medical specialists will be able to find the best package offer for you on the bone marrow transplant cost in Turkey. You will be fully organized the whole process of treatment: starting from the day of contacting the company and up to the complete rehabilitation of the patient after BMT in a Turkish clinic. 

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