Ziya Kalem is an experienced gynecologist and reproductologist with more than 31 years of clinical experience working at Istinye Liv University Hospital. He specializes in the treatment of infertility and female reproductive disorders, including IVF and minimally invasive surgeries.

The doctor’s specialty:

Reproductology:

• Performance of in vitro fertilization (IVF)
• Intracytoplasmic sperm injection (ICSI)
• Intrauterine insemination
• Ovulation induction

Gynecology:

• Laparoscopic and hysteroscopic interventions
• Treatment of chronic pelvic pain
• Diagnosis and therapy of ovarian cysts
• Prevention and treatment of sexually transmitted infections
• Therapy of urinary tract infections
• Diseases of the uterus, vagina and vulva
• Treatment of vaginal candidiasis
• Removal and treatment of uterine myomas
• Pediatric and adolescent gynecology
• Diagnosis and treatment of precancerous diseases of genital organs

• 1981 – Medical Faculty of the University of May 19.
• 1988 – Specialization in Gynecology and Obstetrics, Dr. Zekay Tahir Burak Hospital, Ankara.

Postgraduate education and courses

• Certification in Assisted Reproductive Technology, Ankara Center for Assisted Reproductive Technology.
• 2008 – Specialization in Minimally Invasive Surgery, The Global Open University.

• 1993 – 1995: Gynecologist at Sereflicocisar State Hospital, Ankara.
• 1996 – 2004: Gynecologist at Maternity Hospital, Çorum
• 2005 – 2006: Gynecologist in Private IVF Center, Ankara
• 2006 – 2012: Gynecologist in a private hospital, Çorum
• 2015 – 2019: Specialist in women’s health, infertility treatment and IVF at Gürgan Hospital.
• 2019-present: LIV Hospital of Istinje University and IVF Center of Gürgan Clinic

• Ziya Kalem has authored more than 60 scientific publications in Scientific Reports, The Journal of Maternal-Fetal & Neonatal Medicine, Journal of the Turkish German Gynecological Association, Saudi Medical Journal and others.

He is involved in the study of reproductive medicine, researching infertility problems, mechanisms of embryonic implantation and their relationship with various factors such as endometrial status, hormonal background and other biomarkers. His main areas of research include:

1. Implantation failures and Assisted Reproductive Technology (ART): Kalem is investigating ways to improve embryo implantation in women with repeated failures. Among the methods he is considering are injecting granulocyte colony-stimulating factor (G-CSF) into the uterine cavity to improve implantation, and using herbal supplements such as ginger to improve fertility.
2. Endometrial preparation for embryo transfer cryocycles: A study of different methods of endometrial preparation has shown that the choice of natural or hormone replacement cycles has an impact on the success of cryopreservation.
3. Polycystic ovarian syndrome (PCOS): Kalem’s research involves the effects of drugs such as metformin and oral contraceptives on in vitro fertilization (IVF) cycles in women with PCOS. Biomarkers such as growth factors and enzymes that affect folliculogenesis are also being investigated.
4. Studies of inflammatory markersand growth factors: Kalem’s work shows the relationship between levels of inflammatory markers (NLR, PLR) and birth weight, and the impact of metabolic disorders on pregnancy outcomes.
5. Uterine suturing techniques for cesarean section: Kalem developed a suturing technique for better healing and prevention of isthmocele formation, which reduces the risk of complications in future pregnancies.
6. Role of micronutrients and nutrition: Research on the role of nutrients and micronutrients in pre- and post-pregnancy periods has shown their influence on neonatal weight and reproductive function in the offspring.

• Member of the International Society of Reproductive Medicine.
• Member of the European Association of Gynecologists and Obstetricians.